Routine molecular testing of the nares for the presence of Staphylococcus aureus followed by targeted decolonization of patients carrying either S. aureus (SA) or Methicillin-resistant S. aureus (MRSA) prior to surgery is an effective strategy for preventing surgical site infections (SSIs). It is consistent with both infection prevention and antimicrobial stewardship efforts. This article provides an overview of the value of presurgical molecular testing and targeted decolonization at reducing post-joint replacement SSIs.
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