Decontamination, Disinfection and Sterilization

Infection & Contamination Challenges in Endoscopic Reprocessing

  • Posted: December 17, 2025
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Endoscope reprocessing is a critical component of infection prevention, particularly for high-risk gastrointestinal and respiratory procedures. Despite advances in minimally invasive techniques, the complexity and frequent reuse of endoscopes, especially duodenoscopes used in ERCP procedures, present ongoing contamination risks.

This white paper reviews current research to identify gaps in reprocessing protocols and examines challenges such as biofilm formation, device material compatibility, and transmission of multidrug-resistant organisms (MDROs). It highlights opportunities to enhance patient safety through innovations like hydrogen peroxide gas plasma (HPGP) sterilization and offers guidance on when sterilization may be preferable to high-level disinfection.

Infection preventionists, sterile processing departments, and endoscopy teams can use this resource to strengthen protocols, improve compliance, and minimize infection risk. By understanding evolving practices and technologies, professionals can better protect patients, preserve instrument integrity, and advance the overall safety of endoscopic procedures.

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